N-(benzenesulfonyl)-N-fluorobenzenesulfonamide

CAS 133745-75-2, Cat. No EN300-56237

Reagent for fluorination

N-(benzenesulfonyl)-N-fluorobenzenesulfonamide is a fluorinating reagent, a conventional source of electrophilic fluorine¹. It has similar properties as the famous Selectfluolor but is less reactive and soluble in most organic solvents (ethers, THF, DCM, MeCN, toluene)². It is a white solid with no high melting point (~115℃) and is stable up to 180℃. Therefore, it could be used without solvent in some cases.

Synonyms: N-Fluoro-N-(phenylsulfonyl)benzenesulfonamide (ACI), Accufluor NFSi, Fluorobis(phenylsulfonyl)amine, N-Fluoro-N-(benzenesulfonyl)benzenesulfonamide, N-Fluorobenzenesulfonimide, N-Fluorobis(phenylsulfonyl)amine, N-Fluorodibenzenesulfonimide, N-Phenylsulfonyl-N-fluorobenzenesulfonamide, NFSI

Selected publication

1. Achievements in Fluorination Using Variable Reagents through a Deoxyfluorination Reaction.Aggarwal T.; Sushmita; Verma A. Organic Chemistry Frontiers 2021, 8 (22), 6452–6468. DOI: 10.1039/D1QO00952D

2. N-Fluorobenzenesulfonimide: A Practical Reagent For Electrophilic Fluorinations.Differding E.; Ofner H. Synlett 1991, 1991 (03), 187–189. DOI: 10.1055/s-1991-20673