Diphenyl phosphorochloridate

CAS 2524-64-3, Cat. No EN300-23920

Reagent for phosphorylation

Diphenyl phosphorochloridate is a versatile phosphorylation reagent for synthesizing monoalkyl phosphates, α-substituted β-lactams, anhydrides, esters, thioesters, and enol phosphates¹. Its applications span peptide synthesis, aldoxime to nitrile conversion, and the synthesis of glycosyl phosphates in nucleotide sugar production. Additionally, it is valuable in preparing enol and ketene acetal phosphates for metal-catalyzed coupling reactions. The reagent is a moisture-sensitive, viscous, and colorless liquid that should be stored under nitrogen in a cool, dry place.

Synonyms: diphenyl phosphorochloridate; diphenyl chlorophosphonate; phosphorochloridic acid, diphenyl ester; diphenylchlorophosphate; chlorodiphenoxyphosphine oxide; [chloro(phenoxy)phosphoryl]oxybenzene; diphenyl phosphoryl chloride O,O-diphenyl chlorophosphite

Selected publication

1. Diphenyl Phosphorochloridate.Thomas A.; Buller M.; Kobayashi Y. Encyclopedia of Reagents for Organic Synthesis 2008. DOI: 10.1002/047084289X.rd435.pub2