天然产物
Natural products are biologically active compounds produced by living organisms such as plants, fungi, or animals. They play a crucial role in biological processes and serve as body fluids, metabolites, or even venoms to protect their carrier. Investigation of natural compounds strongly contributes to the understanding of organism biology. These chemicals are often diverse and complex, allowing researchers to discover up-and-coming screening candidates. Paclitaxel, extracted from the pacific vew tree to cure breast cancer, or Penicillin, derived from fungus to treat various bacterial infections, are famous examples of natural compounds that became FDA approved drugs.
Our Library of Natural Products contains 1394 compounds, extracted from nature or nature-like, with information about their activity against biological targets.
Related terms: nature medications, herbal pharmacology, venom pharmaceuticals.
Mechanism of drug-induced liver injury (Created by BioRender.com)
Highlights
Nevirapine is a non-nucleoside reverse transcriptase inhibitor used in the management of HIV-1 virus infection
Colchicine is used in the treatment of gout and Familial Mediterranean Fever
Tiapride is a selective D2 and D3 dopamine receptor blocker in the brain.
BW 755C is a dual inhibitor of 5-lipoxygenase and cyclooxygenase pathways, inhibiting 5-LO, COX-1, and COX-2
Product Features
Library of Natural Products is a set of 1394 bioactive molecules for HTS/HCS programs.
Calculated structural diversity of the collection: 0.89.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
