Most-DILI-Concern药物
DILI (Drug-Induced Liver Injury) is liver damage or injury caused by the use of pharmaceutical drugs or medications. DILI can manifest in various forms, ranging from mild elevations in liver enzymes to severe liver failure. The severity of DILI can vary widely from person to person and depends on the individual's genetics and health, and the drug involved. Healthcare providers and researchers closely monitor the capability of drugs to cause DILI, and regulatory agencies have established guidelines for assessing and mitigating this risk during drug development. Understanding and managing DILI is crucial to ensuring the safety of pharmaceuticals and protecting patients from harm.
The Library of Most-DILI-Concern Drugs comprises a selection of pharmaceutical compounds known for their potential to induce liver injury in patients. These drugs have been extensively studied and documented for their hepatotoxic effects. Researchers and healthcare professionals can use this library for in-depth investigations into DILI mechanisms, risk factors, and possible mitigation strategies. It serves as a valuable resource for advancing our understanding of liver-related adverse drug reactions and improving drug safety profiles.
Related terms: H1 receptor, D2 receptor, carbonic anhydrase, acetylcholinesterase, COX-1, epidermal growth factor receptor, D3 receptor.
Mechanism of drug-induced liver injury (Created by BioRender.com)
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Highlights
Ketoconazole is an anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
Zafirlukast is a leukotriene receptor antagonist used for treatment of asthma.
Tipranavir is a protease inhibitor used to treat HIV-1.
Ritonavir is an inhibitor of HIV protease and Cytochrome P450, used to treat HIV infection and AIDS.
Product Features
A set of 73 bioactive molecules for HTS/HCS programs.
The library is composed of drugs that are the most potential for causing drug-induced liver injury.
Most-DILI-Concern Drugs Library covers only approved drugs.
Calculated structural diversity of the collection: 0.89.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
