FDA获批药物和潜在药物
Clinical trials play a vital role in the discovery of new medicines. They go through a series of phases to test whether a potential drug is safe and whether it works on humans. If the compound successively passes all phases of clinical trials, it can be submitted for FDA (or other pharmaceutical regulatory agency) approval to become a novel drug. Also, a drug with established effectiveness and bioactivity against one disease may be useful in discovering a new drug indication. The process of re-using known drugs to find a new cure for other diseases is called drug repurposing.
FDA Approved and Potential Drugs library is combined of FDA approved drugs, drug repurposing pharmaceuticals, and compounds that passed at least the first phase of clinical trials. It contains 2016 compounds. Additional information about the clinical trials phase and national clinical trial (NCT) numbers is also available to get a review of the clinical success of the substance.
Related terms: H1 receptor, D2 receptor, carbonic anhydrase, 5-HT2A receptor, acetylcholinesterase, COX-1, epidermal growth factor receptor, COX-2, D3 receptor
Highlights
Remdesivir is a nucleoside analog used to treat RNA virus infections.
Zorifertinib is a potent, orally active, central nervous system-penetrant, EGFR inhibitor with IC50 = 0.5nM.
Tiapride is a selective D2 and D3 dopamine receptor blocker in the brain. Tiapride is indicated for the treatment of a variety of neurological and psychiatric disorders
Product Features
FDA Approved and Potential Drugs Library is a set of 2016 bioactive molecules for HTS/HCS programs.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
