已获批药物
FDA (U.S. Food and Drug Administration in the USA), EMA (European Medicines Agency in the European Union), NMPA (National Medical Products Administration in China), and PMDA (Pharmaceuticals and Medical Devices Agency in Japan) are major regulatory agencies ensuring the safety and efficacy of human drugs.
The library of Approved Drugs is composed of 1086 compounds certified by one or few leading pharmaceutical regulatory agencies.
Related terms: H1 receptor, D2 receptor, carbonic anhydrase, 5-HT2A receptor, acetylcholinesterase, COX-1, epidermal growth factor receptor, COX-2, D3 receptor
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Highlights
Avanafil is a potent and highly selective phosphodiesterase-5 (PDE-5) inhibitor. It is used to treat erectile dysfunction
Melperone is an atypical antipsychotic that demonstrates antagonist activity at D2 dopaminergic and 5-HT2A serotonergic receptors
Osalmid is a ribonucleotide reductase small subunit M2 targeting compound
Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID). It potently inhibits both COX-1 and COX-2.
Product Features
Approved Drugs Library is a set of 1086 bioactive molecules for HTS/HCS programs.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
