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Ion channels are a large group of membrane proteins, also called the passive-transport systems, characterized by a very high ion-transport rate. Ion channels are represented in almost every type of living cell, as well as in cell organelles. They play a principal role in cell homeostasis and can be considered therapeutic targets for CNS disorders, pain control, inflammatory processes, cardiovascular diseases, and some pathogenic diseases. While many efficient ion channel-targeting drugs exist, these molecules remain a highly unexplored group of proteins.
Ion Channel Ligands Library is composed of 1044 small molecules. The library covers ligands suitable for application in many medicinal areas: cardiovascular regulation, neuroscience, pain suppression, and immune response regulation.
Related terms: CFTR, L-type calcium channel, Kv11.1, 5-HT3A, GABAA receptor, TRPA1, GluN2D, NMDA receptor, TRPV1, nicotinic acetylcholine receptor
Action of ion channel(Created by BioRender.com)
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Highlights
Amiodarone, antiarrythmic
Ro4938581, nootripic
Vecuronium bromide, anesthetic
Loratadine, antihistamine
Product Features
A set of 1044 ion channel binding molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
The library is composed of ligands that target all major pharmaceutically relevant ion channel targets.
Ion Channel Ligands Library covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
Calculated structural diversity of the collection: 0.88.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficients values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
