生长因子和细胞因子配体
Cytokines are signal molecules that bind to the receptor proteins on the surface of immune system cells, provoking an immunological response. They include chemokines, interferons, interleukins, lymphokines, and tumor necrosis factors. Growth factors are important molecules for the regulation of a variety of cellular processes. These compounds stimulate cell proliferation, regeneration, and cell differentiation. Together cytokines and growth factors are weighty parts of the immune system's responses to infection, inflammation, trauma, sepsis, cancer and reproduction, becoming prominent pharmaceutical targets.
Growth Factors and Cytokines Ligands Library contains 414 small ligands, some representative molecules are given below: Ceritinib, ALK tyrosine kinase receptor inhibitor; Lucitanib, VEGFR and FGFR inhibitor; MSX-127, CXCR4 antagonist; Eltrombopag, Thrombopoietin receptor agonist.
Related terms: epidermal growth factor, fms related receptor tyrosine kinase, kinase insert domain receptor, fibroblast growth factor, platelet derived growth factor
Biological action of cytokines on TPO receptor(Created by BioRender.com)
Highlights
Ceritinib, ALK tyrosine kinase receptor inhibitor
Lucitanib, VEGFR and FGFR inhibitor
MSX-127, CXCR4 antagonist
Eltrombopag, Thrombopoietin receptor agonist
Product Features
A set of 414 growth factors and cytokynes relevant molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
The library is composed of ligands that target all major pharmaceutically relevant growth factors and cytokynes targets.
Growth Factors and Cytokynes Ligands Library covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
Calculated structural diversity of the collection: 0.85.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
