细胞凋亡相关配体
Apoptosis is one of the programmed cell death (PDC) mechanisms in multicellular organisms. Biochemical cascade leads to morphological cell changes (cell shrinking, nuclear fragmentation, etc.) and death. This process is critical for maintaining the health of the organism by eliminating old or unhealthy cells. Apoptosis is controlled by Fas receptor and caspases (pro-apoptotic signaling) and Bcl-2/IAP (anti-apoptotic factors). The disbalance in the mechanism of apoptosis leads to atrophy in case of overstimulation, or cancer and related diseases in case of its suppression(the cells become “immortal”). It makes both processes of apoptosis (inhibition and stimulation) an important target for modern pharmacy and drug development.
Apoptosis Related Ligands Library contains 352 small ligands, some representative molecules are given below: SP141, MDM2 inhibitor; ML-311, Mcl-1 inhibitor; Sepantronium bromide, a baculoviral IAP repeat containing 5 inhibitor.
Related terms: MDM2 proto-oncogene, caspase, calpain 2, Bcl-2-like 1
Apoptosis signaling pathways (Created by BioRender.com)
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Highlights
SP141, Mdm2 inhibitor
ML-311, Mcl-1 inhibitor
Sepantronium bromide, baculoviral IAP repeat containing 5 inhibitor
Product Features
A set of 352 apoptosis related molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
The library is composed of ligands that target all major pharmaceutically relevant apoptosis related targets.
Apoptosis Related Ligands Library covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
Calculated structural diversity of the collection: 0.86.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
