信号转导相关配体
Signal transduction allows an organism to sense its environment and formulate the proper biochemical response. The proteins responsible for the mediation of information are generally called receptors. The changes induced by ligand binding in a receptor initiate biochemical cascades, known as signaling pathways. These cascades are the key mechanisms for the control of cell growth, proliferation, metabolism, and many other processes. So, a small ligand can interfere with and regulate the cell signal transduction processes, forming an important instrument for modern medicinal chemistry, as well as a therapeutic practice.
Signal Transduction Related Ligands Library contains 944 small ligands, some representative molecules are given below: Selatinib, EGFR/HER-2 inhibitor; XAV-939, Tankyrase1/2 inhibitor; G10, agonist of stimulator of STING; Fedratinib, Broad spectrum kinase inhibitor.
Related terms: epidermal growth factor, Janus kinase, kinase insert domain receptor, aryl hydrocarbon receptor, glycogen synthase kinase, mitogen-activated protein kinase, fibroblast growth factor
Signal transduction pathways in mammalian cell (Created by BioRender.com)
Highlights
Selatinib, EGFR/HER-2 inhibitor
XAV-939, Tankyrase1/2 inhibitor
G10, agonist of stimulator of STING
Fedratinib, Broad spectrum kinase inhibitor
Product Features
A set of 944 signal transduction relevant molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
The library is composed of ligands that target all major pharmaceutically relevant signal transduction related targets.
Signal Transduction Related Ligands Library covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
clinical candidates and approved drugs.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
