血管生成相关配体
Angiogenesis is the essential physiological process of the formation of new blood vessels from existing ones, formed earlier at the stage of vasculogenesis. It is a crucial process for the growth and development of the human body, as well as for wound healing by the formation of granulation tissue. Disorders in the angiogenesis-related signaling pathways lead to cancer or cardiovascular diseases. These diseases can be controlled by exogenous angiogenesis activators (cardiovascular) or inhibitors (cancer). Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. The angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc.
Angiogenesis Related Ligands Library consists of 760 small ligands, some representative molecules are given below: TSC359, FLT3 inhibitor; ML106, DYRK1A inhibitor; DB04760, Collagenase 3 inhibitor; Fedratinib, Cyclin-G-associated kinase inhibitor.
Related terms: COX-1 , COX-2, epidermal growth factor, fms related receptor tyrosine kinase, platelet derived growth factor, fibroblast growth factor, AT1 receptor, MMP8
Representation of the connection between angiogenesis and cancer tumor growth (Created By BioRender.com)
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Highlights
TCS 359, FLT3 inhibitor
ML106, DYRK1A inhibitor
DB04760, Collagenase 3 inhibitor
Fedratinib, Cyclin-G-associated kinase inhibitor
Product Features
A set of 760 angiogenesis relevant molecules with sub-10 micromolar activity coefficient values for HTS/HCS programs.
The library is composed of ligands that target all major pharmaceutically relevant angiogenesis targets.
Angiogenesis Related Ligands Library covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
Calculated structural diversity of the collection: 0.86.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
