生物活性化合物 III
Bioactive Library II is a collection of 1444 compounds with annotated biological activity. This collection is based on Bioactive Library I and contains compounds with sub-one micromolar activity coefficient values only.
- Fully annotated: all compounds are provided with literature references and detailed and up to date biological activity data.
- Custom Synthesis and Compound Sourcing: we can supply almost any compound either via in-house synthesis or using our supplier network.
Related terms: GPCR, carbonic anhydrase, ligand-gated ion channel, receptor tyrosine kinase, RTK, nRTK, cytochrome P450, voltage-gated ion channel, oxidoreductase, catecholamine turnover
Highlights
Etodolac is a non-steroidal anti-inflammatory drug (NSAID). It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis.
RU 24969 is a 5-hydroxytryptamine receptor 1b inhibitor with Ki (inhibition constant) = 0.43 nM
2,4-Dichloro-5-sulfamoylbenzoic acid is a carbonic anhydrase inhibitor with Kd (dissociation constant) = 0.14 nM
Product Features
Enamine Bioactive Library I is a set of 3872 bioactive molecules for HTS/HCS programs.
The Bioactive Library I covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
