生物活性化合物 II
Bioactive Library II is a collection of 3872 compounds with annotated biological activity. This collection is based on Bioactive Library I and contains compounds with sub-one micromolar activity coefficient values only.
- Fully annotated: all compounds are provided with literature references and detailed and up to date biological activity data.
- Custom Synthesis and Compound Sourcing: we can supply almost any compound either via in-house synthesis or using our supplier network.
Related terms: GPCR, carbonic anhydrase, ligand-gated ion channel, receptor tyrosine kinase, RTK, nRTK, cytochrome P450, voltage-gated ion channel, oxidoreductase, catecholamine turnover
Highlights
Olopatadine is a selective histamine H1 antagonist and mast cell stabilizer that works by attenuating inflammatory and allergic reactions.
DHP-053 is a blocker of voltage-dependent L-type calcium channel.
TCS 359 is an inhibitor of receptor-type tyrosine-protein kinase FLT3.
AS1842856 is a specific Foxo1 inhibitor, it potently suppresses autophagy.
Product Features
Enamine Bioactive Library I is a set of 3872 bioactive molecules for HTS/HCS programs.
The Bioactive Library I covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
