生物活性化合物 I
Bioactive Library I: we have synthesized and collected 5562 compounds with known biological activity, including over 1100 FDA-approved drugs, tool compounds, metabolites, prodrugs, and drug candidates.
- Fully annotated: all compounds are provided with literature references and detailed and up to date biological activity data.
- Custom Synthesis and Compound Sourcing: we can supply almost any compound either via in-house synthesis or using our supplier network.
Related terms: GPCR, carbonic anhydrase, ligand-gated ion channel, receptor tyrosine kinase, RTK, nRTK, cytochrome P450, voltage-gated ion channel, oxidoreductase, catecholamine turnover
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Highlights
KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor, IC50 = 14nM.
Compound shows binding affinity to adenosine receptor a2a, Ki = 1.21 µM.
Ropinirole is a non-ergoline dopamine agonist. It is used for the treatment of the signs and symptoms of Parkinson's disease
Canagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor used to manage hyperglycemia in type 2 diabetes mellitus
Product Features
Enamine Bioactive Library I is a set of 5562 bioactive molecules for HTS/HCS programs.
The Bioactive Library I covers novel promising preclinical lead compounds, clinical candidates and approved drugs.
Comprehensive documentation with structures, trivial names, synonyms, activity coefficient values, types of action on target and references to original literature.
NMR and LCMS validated purity.
All the compounds are available in stock for hit follow-up.
The library is continuously updated.
Product Details
Format: 10 - 100 µL of 10 mM DMSO stock solutions; dry powders (1 mg);
Container: 384-well microplates;
Storage: - 18 °C;
Shipping: Dry ice.
Utility
High throughput screening (HTS);
High content screening (HCS);
Cherry picking.
