This file contains virtual macrocyclic scaffolds that can potentially be synthesized. Our parallel chemistry department may attempt to synthesize milligram quantities of these molecules.
Typically, syntheses involve 4–5 steps, which results in a lower synthetic success rate and higher cost compared to Enamine REAL compounds.

Please note:

These compounds are available only via custom synthesis, with pricing provided upon request.
They are not included in our official REAL database releases or general distribution files.
The molecules in this file are exclusive to this dataset and do not appear in any other shared resources.